What research findings exist regarding LL37 on antibacterial effects, wound healing, and barrier repair?
LL-37/EGCG-containing scaffolds improve neovascularization, collagen tissue, and local inflammation. Other studies report that LL-37 promotes wound closure, an effect related to TFEB-dependent autophagy.[1] ↗ [2] ↗
Currently, 3 original studies related to the theme of this page have been selected. The number of studies includes different designs, populations, or preparations, not commercial clinical efficacy ratings. This page is a usage-oriented positive data selection, not a systematic review or dosing recommendation. Historical studies, combination preparations, and special models are all separately indicated.
Comparison of study design and results
Results from different populations, species, materials, or follow-up times cannot be directly combined. The table below is a comparative summary of published data, not new experimental data.
| Literature | Study subjects and design | Observation and discovery | Scope of Explanation |
|---|---|---|---|
| 2026 · PMID 42445046 | Rat gingival soft tissue and cells; composite hydrogel | LL-37/EGCG-containing scaffolds improve neovascularization, collagen tissue, and local inflammation. | Composite materials cannot be entirely attributed to LL-37. |
| 2024 · PMID 38423213 | Diabetic mouse wound and keratinocyte experiments | LL-37 promotes wound closure, and its effect is related to TFEB-dependent autophagy. | Animal and cellular mechanism studies, do not prove human wound efficacy of ordinary bottled materials. |
| 2023 · PMID 37480520 | Patients with mild diabetic foot infection; 4-week LL-37 cream randomized double-blind trial | Improvement in granulation tissue formation indicators in the cream group, supports local wound repair studies. | Reduction in inflammatory factors and bacterial colonization did not reach significant differences between groups; cannot be considered confirmed antibacterial or injection efficacy. |
References
How should the gingival soft tissue repair study of the composite scaffold be interpreted?
LL-37/EGCG-containing scaffolds improve neovascularization, collagen tissue, and local inflammation.[1] ↗
Rat gingival soft tissue and cells; composite hydrogel
Composite materials cannot be entirely attributed to LL-37.
View the Article Title and Full Citation＋
A degradable hydrogel scaffold incorporating the LL-37 for gingival soft tissue regeneration.
Regenerative biomaterials · Volume and Issue Year 2026
First published 2026-01-01 · PMID 42445046
DOI 10.1093/rb/rbag131
What is the wound healing mechanism in diabetic mice?
LL-37 promotes wound closure, and its effect is related to TFEB-dependent autophagy.[2] ↗
Diabetic mouse wound and keratinocyte experiments
Animal and cellular mechanism studies, do not prove human wound efficacy of ordinary bottled materials.
View the Article Title and Full Citation＋
Cathelicidin LL-37 promotes wound healing in diabetic mice by regulating TFEB-dependent autophagy.
Peptides · Volume and Issue Year 2024
First published 2024-02-28 · PMID 38423213
DOI 10.1016/j.peptides.2024.171183
What improvements did the diabetic foot cream trial achieve?
Improvement in granulation tissue formation indicators in the cream group, supports local wound repair studies.[3] ↗
Patients with mild diabetic foot infection; 4-week LL-37 cream randomized double-blind trial
Reduction in inflammatory factors and bacterial colonization did not reach significant differences between groups; cannot be considered confirmed antibacterial or injection efficacy.
View the Article Title and Full Citation＋
Efficacy of LL-37 cream in enhancing healing of diabetic foot ulcer: a randomized double-blind controlled trial.
Archives of Dermatological Research · Volume and Year 2023
First published 2023-07-22 · PMID 37480520
DOI 10.1007/s00403-023-02657-8
Common issues and corresponding evidence
What research findings exist regarding LL37 on antibacterial effects, wound healing, and barrier repair?＋
LL-37/EGCG-containing scaffolds improve neovascularization, collagen tissue, and local inflammation. Other studies report that LL-37 promotes wound closure, an effect related to TFEB-dependent autophagy.[1] ↗ [2] ↗
Does LL-37 wound research simultaneously confirm clinical antibacterial effects?＋
Not necessarily. The diabetic foot cream trial improved granulation formation, but the decrease in inflammatory factors and bacterial colonization between groups was not significant; repair endpoints cannot replace antibacterial endpoints.[3] ↗
LL37—these conclusions apply to which study populations?＋
Rat gingival soft tissue and cells; composite hydrogel; diabetic mouse wound and keratinocyte experiments; mild infection in diabetic foot patients; 4-week LL-37 cream randomized double-blind trial. Composite material, cannot be fully attributed to LL-37.[1] ↗ [2] ↗ [3] ↗
LL37
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