LL37375

Images are illustrative. Actual specifications are as selected and confirmed in writing.

Repair & Recovery Research

LL37

Antimicrobial activity, wounds and barrier repair

LL37 specifications and reference prices. Select a specification to add it to your cart.

5mg/vial x 10vials

Reference priceUS$236.36

For laboratory research only. Not for human or veterinary use.

COA 检测报告 / Reports

Compare all specifications & reference prices
SKUSpecification / packReference price (USD)
3755mg/vial x 10vialsUS$236.36

Temporarily sold-out specifications can still be added to an inquiry to ask about restocking. An inquiry is not an order or an agreed price.

RESEARCH FOCUS

Main Uses & FAQs

This page organizes directly related information on antibacterial activity, wound, and barrier repair of LL37. First, look at the research questions and findings, then verify the population or species, study preparations, and scope of interpretation.

Main TopicsAntibacterial · wound · barrier repair
USAGE REFERENCE

LL-37 · Usage reference (for research purposes)

The following presents common research-context references for reconstitution, storage, dosage and cycles. The following presents common references in research settings. This page does not constitute advice for use in humans or animals.

🧪Reconstitution

Suggested Diluent
Bacteriostatic Water (containing 0.9% benzyl alcohol); some peptides may use sterile water or acetic acid to aid dissolution. See the individual product descriptions.
Diluent Volume
Slowly introduce the diluent along the vial wall until the lyophilized powder is covered. A common example is 5 mg reconstituted with 2 mL of bacteriostatic water, yielding approximately 2.5 mg/mL. Referenced reconstitution volumes are approximately 1–2.5 mL, with 2 mL commonly used. It is suggested to select and record a fixed volume based on the COA supplied with the purchase.
Handling Notes
Introduce the diluent slowly along the vial wall rather than directly onto the lyophilized powder. Leave it for 60–90 seconds to dissolve naturally; do not shake vigorously.

💾Storage

Unreconstituted Lyophilized Powder
Refrigerate at 2–8°C, protected from light; avoid repeated freeze–thaw cycles.
After Reconstitution
Refrigerate at 2–8°C; a common recommendation is touse within 28 days; do not freeze.
Transport
For short periods, use insulated packaging with ice packs; avoid high temperatures and direct light.

📏Dosage Reference (Research)

Purpose / SettingCommon Reference
ExplanationAntimicrobial peptides, mostly for research use; limited community protocols

Note: The above describes common research-context references, rather than clinical recommendations. Refer to the batch COA and research protocol. For research use only; not for human or animal use.

Research SummaryKey Findings

What research findings exist regarding LL37 on antibacterial effects, wound healing, and barrier repair?

LL-37/EGCG-containing scaffolds improve neovascularization, collagen tissue, and local inflammation. Other studies report that LL-37 promotes wound closure, an effect related to TFEB-dependent autophagy.[1] ↗ [2] ↗

Before ReadingStudy populations, species, formulations and delivery conditions each have a defined scope. Research on an ingredient does not establish that this site's product batches have been validated for efficacy in humans or veterinary use.
3 Main ReferencesSorted by First Publication Date ↓
Animal / experimental studies2026REF. 01

How should the gingival soft tissue repair study of the composite scaffold be interpreted?

Research Findings

LL-37/EGCG-containing scaffolds improve neovascularization, collagen tissue, and local inflammation.[1] ↗

Study Design

Rat gingival soft tissue and cells; composite hydrogel

Scope & Limitations

Composite materials cannot be entirely attributed to LL-37.

View the Article Title and Full Citation+

A degradable hydrogel scaffold incorporating the LL-37 for gingival soft tissue regeneration.

Mao J, Li X, Liao K, Liu L, Zheng H, Cui Y, Guo Z, Song K, Zhao J, Wu L, Zhang W, Chen J, Li W

Regenerative biomaterials · Volume and Issue Year 2026
First published 2026-01-01 · PMID 42445046
DOI 10.1093/rb/rbag131

Animal / experimental studies2024REF. 02

What is the wound healing mechanism in diabetic mice?

Research Findings

LL-37 promotes wound closure, and its effect is related to TFEB-dependent autophagy.[2] ↗

Study Design

Diabetic mouse wound and keratinocyte experiments

Scope & Limitations

Animal and cellular mechanism studies, do not prove human wound efficacy of ordinary bottled materials.

View the Article Title and Full Citation+

Cathelicidin LL-37 promotes wound healing in diabetic mice by regulating TFEB-dependent autophagy.

Xi L, Du J, Xue W, Shao K, Jiang X, Peng W, Li W, Huang S

Peptides · Volume and Issue Year 2024
First published 2024-02-28 · PMID 38423213
DOI 10.1016/j.peptides.2024.171183

Human Study2023REF. 03

What improvements did the diabetic foot cream trial achieve?

Research Findings

Improvement in granulation tissue formation indicators in the cream group, supports local wound repair studies.[3] ↗

Study Design

Patients with mild diabetic foot infection; 4-week LL-37 cream randomized double-blind trial

Scope & Limitations

Reduction in inflammatory factors and bacterial colonization did not reach significant differences between groups; cannot be considered confirmed antibacterial or injection efficacy.

View the Article Title and Full Citation+

Efficacy of LL-37 cream in enhancing healing of diabetic foot ulcer: a randomized double-blind controlled trial.

Miranda E, Bramono K, Yunir E, Reksodiputro MH, Suwarsa O, Rengganis I, Harahap AR, Subekti D, Suwarto S, Hayun H, Bardosono S, Baskoro JC

Archives of Dermatological Research · Volume and Year 2023
First published 2023-07-22 · PMID 37480520
DOI 10.1007/s00403-023-02657-8

i

Currently, 3 original studies related to the theme of this page have been selected. The number of studies includes different designs, populations, or preparations, not commercial clinical efficacy ratings. This page is a usage-oriented positive data selection, not a systematic review or dosing recommendation. Historical studies, combination preparations, and special models are all separately indicated.

GO DEEPER

What Questions Do These Studies Address?

Compare study populations, findings and scope.

↗
QUESTIONS, ANSWERED

LL37 · Frequently Asked Questions.

What research findings exist regarding LL37 on antibacterial effects, wound healing, and barrier repair?+

LL-37/EGCG-containing scaffolds improve neovascularization, collagen tissue, and local inflammation. Other studies report that LL-37 promotes wound closure, an effect related to TFEB-dependent autophagy.[1] ↗ [2] ↗

Does LL-37 wound research simultaneously confirm clinical antibacterial effects?+

Not necessarily. The diabetic foot cream trial improved granulation formation, but the decrease in inflammatory factors and bacterial colonization between groups was not significant; repair endpoints cannot replace antibacterial endpoints.[3] ↗

LL37—these conclusions apply to which study populations?+

Rat gingival soft tissue and cells; composite hydrogel; diabetic mouse wound and keratinocyte experiments; mild infection in diabetic foot patients; 4-week LL-37 cream randomized double-blind trial. Composite material, cannot be fully attributed to LL-37.[1] ↗ [2] ↗ [3] ↗

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