AICARAR50

Images are illustrative. Actual specifications are as selected and confirmed in writing.

Longevity & Mitochondrial Research

AICAR

AMPK metabolism and exercise capacity

AICAR specifications and reference prices. Select a specification to add it to your cart.

50mg/vial x 10vials
Reference priceUS$79

For laboratory research only. Not for human or veterinary use.

COA 检测报告 / Reports

Compare all specifications & reference prices
SKUSpecification / packReference price (USD)
AR5050mg/vial x 10vialsUS$79
AR100100mg/vial x 10vialsUS$123

Temporarily sold-out specifications can still be added to an inquiry to ask about restocking. An inquiry is not an order or an agreed price.

RESEARCH FOCUS

Main Uses & FAQs

This page organizes directly relevant information on AICAR regarding AMPK metabolism and exercise capacity. First, review the research questions and findings, then verify the population or species, study formulations, and scope of interpretation.

Main TopicsAMPK metabolism · exercise performance
USAGE REFERENCE

AICAR · Usage reference (for research purposes)

The following presents common research-context references for reconstitution, storage, dosage and cycles. The following presents common references in research settings. This page does not constitute advice for use in humans or animals.

🧪Reconstitution

Suggested Diluent
Bacteriostatic Water (containing 0.9% benzyl alcohol); some peptides may use sterile water or acetic acid to aid dissolution. See the individual product descriptions.
Diluent Volume
Slowly introduce the diluent along the vial wall until the lyophilized powder is covered. A common example is 5 mg reconstituted with 2 mL of bacteriostatic water, yielding approximately 2.5 mg/mL. Referenced reconstitution volumes are approximately 1–2.5 mL, with 2 mL commonly used. It is suggested to select and record a fixed volume based on the COA supplied with the purchase.
Handling Notes
Introduce the diluent slowly along the vial wall rather than directly onto the lyophilized powder. Leave it for 60–90 seconds to dissolve naturally; do not shake vigorously.

💾Storage

Unreconstituted Lyophilized Powder
Refrigerate at 2–8°C, protected from light; avoid repeated freeze–thaw cycles.
After Reconstitution
Refrigerate at 2–8°C; a common recommendation is touse within 28 days; do not freeze.
Transport
For short periods, use insulated packaging with ice packs; avoid high temperatures and direct light.

📏Dosage Reference (Research)

Purpose / SettingCommon Reference
ExplanationAMPK metabolism research

🔁Cycle

According to exercise/metabolic research protocol.

View the Complete Usage Guide Library →

Note: The above describes common research-context references, rather than clinical recommendations. Refer to the batch COA and research protocol. For research use only; not for human or animal use.

Research SummaryKey Findings

What have studies found about AICAR regarding AMPK metabolism and exercise performance?

Maintained treadmill performance and improved some muscle mass and strength, aligning with exercise and muscle metabolism focus. Additional studies report: AICAR reduces body weight and abdominal fat and improves some metabolic pathology indicators.[1] ↗ [2] ↗

Before ReadingStudy populations, species, formulations and delivery conditions each have a defined scope. Research on an ingredient does not establish that this site's product batches have been validated for efficacy in humans or veterinary use.
3 Main ReferencesSorted by First Publication Date ↓
Animal Study2025REF. 01

How do the motor performance and muscle strength of aged mice change?

Research Findings

Maintained treadmill performance and improved some muscle mass and strength, aligning with exercise and muscle metabolism focus.[1] ↗

Study Design

23-month-old mice; 31 days of AICAR administration

Scope & Limitations

Research on aged mice cannot be extrapolated to exercise gains or general anti-aging effects in healthy humans.

View the Article Title and Full Citation+

Chronic treatment of old mice with AICAR reverses age-related changes in exercise performance and skeletal muscle gene expression.

Wilcox SH, Calixto J, Dray SD, Rasch DM, Smith AH, Brodowski KD, Hill JT, Thomson DM

FASEB BioAdvances · Volume and Issue Year 2025
First published 2025-01-29 · PMID 40060947
DOI 10.1096/fba.2024-00252

Animal Study2022REF. 02

What changes occur in body fat and metabolism in high-fat diet mice?

Research Findings

AICAR reduces body weight and abdominal fat and improves some metabolic pathology indicators.[2] ↗

Study Design

High-fat diet C57BL/6 male mouse metabolic syndrome model

Scope & Limitations

The study also observed hepatotoxicity under early dosing conditions with a standard diet; conditions cannot be omitted and do not support human weight loss claims.

View the Article Title and Full Citation+

AICAR Improves Outcomes of Metabolic Syndrome and Type 2 Diabetes Induced by High-Fat Diet in C57Bl/6 Male Mice.

Tukhovskaya EA, Shaykhutdinova ER, Pakhomova IA, Slashcheva GA, Goryacheva NA, Sadovnikova ES, Rasskazova EA, Kazakov VA, Dyachenko IA, Frolova AA, Brovkin AN, Kaluzhsky VE, Beburov MY, Murashev AN

International Journal of Molecular Sciences · Volume/Issue/Year 2022
First published 2022-12-11 · PMID 36555360
DOI 10.3390/ijms232415719

Animal Study2008 · Historical basic researchREF. 03

What were the findings of classic treadmill endurance studies on AICAR?

Research Findings

AICAR alone improves treadmill endurance in mice and induces some metabolism-related genes, providing a basis for AMPK exercise adaptation mechanisms.[3] ↗

Study Design

Mice; 4-week AICAR intervention and treadmill endurance study

Scope & Limitations

2008 animal basic research; other groups had different PPARδ interventions, not equivalent to effects on humans without exercise.

View the Article Title and Full Citation+

AMPK and PPARdelta agonists are exercise mimetics.

Narkar VA, Downes M, Yu RT, Embler E, Wang YX, Banayo E, Mihaylova MM, Nelson MC, Zou Y, Juguilon H, Kang H, Shaw RJ, Evans RM

Cell · Volume and issue year 2008
First published 2008-07-31 · PMID 18674809
DOI 10.1016/j.cell.2008.06.051

i

Currently, 3 original studies related to the theme of this page have been selected. The number of studies includes different designs, populations, or preparations, not commercial clinical efficacy ratings. This page is a usage-oriented positive data selection, not a systematic review or dosing recommendation. Historical studies, combination preparations, and special models are all separately indicated.

GO DEEPER

What Questions Do These Studies Address?

Compare study populations, findings and scope.

↗
QUESTIONS, ANSWERED

AICAR · Frequently Asked Questions.

What have studies found about AICAR regarding AMPK metabolism and exercise performance?+

Maintained treadmill performance and improved some muscle mass and strength, aligning with exercise and muscle metabolism focus. Additional studies report: AICAR reduces body weight and abdominal fat and improves some metabolic pathology indicators.[1] ↗ [2] ↗

Can AICAR be considered a validated human exercise substitute?+

Not allowed. Studies on aged mice focus on treadmill performance and muscle indicators, and high-fat diet mice studies focus on body fat and metabolism; neither can be directly extrapolated to human exercise or weight loss effects.[1] ↗ [2] ↗

AICAR—these conclusions apply to which study populations?+

23-month-old mice; 31 days of AICAR administration; high-fat diet C57BL/6 male mice metabolic syndrome model; mice; 4-week AICAR intervention and treadmill endurance study. Aged mouse study, cannot extrapolate to exercise gains or general anti-aging effects in healthy humans.[1] ↗ [2] ↗ [3] ↗

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