Research SummaryKey Findings

What research findings are there on ACE 031 regarding muscle mass and muscle function?

Improvement in lean body mass, muscle fiber cross-sectional area, and ex vivo muscle strength indicators. Other studies report: in higher dose group, 29-day increase in lean body mass and thigh muscle volume.[1] ↗ [2] ↗

Before ReadingStudy populations, species, formulations and delivery conditions each have a defined scope. Research on an ingredient does not establish that this site's product batches have been validated for efficacy in humans or veterinary use.
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Currently, 3 original studies related to the theme of this page have been selected. The number of studies includes different designs, populations, or preparations, not commercial clinical efficacy ratings. This page is a usage-oriented positive data selection, not a systematic review or dosing recommendation. Historical studies, combination preparations, and special models are all separately indicated.

Comparison of study design and results

Results from different populations, species, materials, or follow-up times cannot be directly combined. The table below is a comparative summary of published data, not new experimental data.

LiteratureStudy subjects and designObservation and discoveryScope of Explanation
2026 · PMID 41686840Common marmosets; ACE-031 administrationImprovement in lean body mass, muscle fiber cross-sectional area, and ex vivo muscle strength indicators.Non-human primates; product must correspond to ActRIIB-Fc fusion protein.
2013 · PMID 2316960748 healthy postmenopausal women randomized single-dose study.Higher dose group showed increased lean body mass and thigh muscle volume after 29 days.2013, short-term; does not represent exercise function or long-term therapeutic benefits.
2010 · PMID 20466801C57BL/6 mice; ACE-031 administered for 28 daysMultiple groups showed increases in skeletal muscle mass and muscle fiber cross-sectional area.2010; Changes in muscle mass cannot replace evidence of human exercise function.

References

Animal Study2026REF. 01

How do the muscle mass and strength indicators of marmosets change?

Research Findings

Improvement in lean body mass, muscle fiber cross-sectional area, and ex vivo muscle strength indicators.[1] ↗

Study Design

Common marmosets; ACE-031 administration

Scope & Limitations

Non-human primates; product must correspond to ActRIIB-Fc fusion protein.

View the Article Title and Full Citation＋

ACE-031, a soluble activin type IIB receptor, increases muscle mass and strength in the common marmoset (Callithrix jacchus).

Cadena SM, Bogdanovich S, Khurana TS, Pullen A, Pearsall RS, Curran E, Faucette R, Lane J, Seehra J, Lachey JL, Mizener AD, Pistilli EE.

PLoS One · Volume and Issue Year 2026
First published 2026-02-13 · PMID 41686840
DOI 10.1371/journal.pone.0342666

Published · Original ResearchPubMed ↗Journal Article ↗
Human Study2013 · Historical basic researchREF. 02

How were lean body mass and muscle volume in early human trials?

Research Findings

Higher dose group showed increased lean body mass and thigh muscle volume after 29 days.[2] ↗

Study Design

48 healthy postmenopausal women randomized single-dose study.

Scope & Limitations

2013, short-term; does not represent exercise function or long-term therapeutic benefits.

View the Article Title and Full Citation＋

A single ascending-dose study of muscle regulator ACE-031 in healthy volunteers.

Attie KM, Borgstein NG, Yang Y, Condon CH, Wilson DM, Pearsall AE, Kumar R, Willins DA, Seehra JS, Sherman ML.

Muscle & nerve · Volume/Issue Year 2013
First published on 2012-11-21 · PMID 23169607
DOI 10.1002/mus.23539

Published · Original ResearchPubMed ↗Journal Article ↗
Animal Study2010 · Historical basic researchREF. 03

Changes in animal skeletal muscle weight and muscle fiber area?

Research Findings

Multiple groups showed increases in skeletal muscle mass and muscle fiber cross-sectional area.[3] ↗

Study Design

C57BL/6 mice; ACE-031 administered for 28 days

Scope & Limitations

2010; Changes in muscle mass cannot replace evidence of human exercise function.

View the Article Title and Full Citation＋

Administration of a soluble activin type IIB receptor promotes skeletal muscle growth independent of fiber type.

Cadena SM, Tomkinson KN, Monnell TE, Spaits MS, Kumar R, Underwood KW, Pearsall RS, Lachey JL.

Journal of Applied Physiology (Bethesda, Md. : 1985) · Volume and Issue Year 2010
First published on 2010-05-13 · PMID 20466801
DOI 10.1152/japplphysiol.00866.2009

Published · Original ResearchPubMed ↗Journal Article ↗

Common issues and corresponding evidence

What research findings are there on ACE 031 regarding muscle mass and muscle function?＋

Improvement in lean body mass, muscle fiber cross-sectional area, and ex vivo muscle strength indicators. Other studies report: in higher dose group, 29-day increase in lean body mass and thigh muscle volume.[1] ↗ [2] ↗

Does an increase in lean body mass from ACE-031 mean improved muscle function?＋

cannot be directly equated. Early human studies mainly looked at lean body mass and thigh muscle volume, while animal studies included different muscle function indicators; it is also necessary to confirm that the product is the corresponding fusion protein.[2] ↗ [1] ↗

ACE 031—these conclusions apply to which study populations?＋

Common marmosets; ACE-031 administration; single-dose study in 48 healthy postmenopausal women; C57BL/6 mice; ACE-031 administration for 28 days. Non-human primates; product must correspond to ActRIIB-Fc fusion protein.[1] ↗ [2] ↗ [3] ↗

ACE 031

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