Research SummaryKey Findings

What research findings exist regarding PE-22-28 in antidepressant-like behavior and neural plasticity?

PE22-28 shows research potential in antidepressant-like behavior, neurogenesis, and synapse formation.[1] ↗

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Currently Selected 1 Original Study Related to the Theme of This Page. Fewer than 3 studies, the gap is retained, no other uses are added to fill the number. This page is a purposive collection of positive information, not a systematic review or dosage recommendation. Historical studies, combination formulations, and special models are separately indicated.

Comparison of study design and results

Results from different populations, species, materials, or follow-up times cannot be directly combined. The table below is a comparative summary of published data, not new experimental data.

LiteratureStudy subjects and designObservation and discoveryScope of Explanation
2017 · PMID 28955242Mouse behavioral experiments and neuron culturePE22-28 shows research potential in antidepressant-like behavior, neurogenesis, and synapse formation.2017; currently only 1 core original study directly related to this body.

References

Animal Study2017 · Historical basic researchREF. 01

What findings exist regarding the antidepressant-like behavior and plasticity of PE-22-28?

Research Findings

PE22-28 shows research potential in antidepressant-like behavior, neurogenesis, and synapse formation.[1] ↗

Study Design

Mouse behavioral experiments and neuron culture

Scope & Limitations

2017; currently only 1 core original study directly related to this body.

View the Article Title and Full Citation＋

Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity.

Djillani A, Pietri M, Moreno S, Heurteaux C, Mazella J, Borsotto M.

Frontiers in Pharmacology · Volume and Issue Year 2017
First published 2017-09-12 · PMID 28955242
DOI 10.3389/fphar.2017.00643

Published · Original ResearchPubMed ↗Journal Article ↗

Common issues and corresponding evidence

What research findings exist regarding PE-22-28 in antidepressant-like behavior and neural plasticity?＋

PE22-28 shows research potential in antidepressant-like behavior, neurogenesis, and synapse formation.[1] ↗

Does the antidepressant-like effect in PE-22-28 research come from humans?＋

The core information on this page is from preclinical studies, involving behavior, neurogenesis, and synaptic-related endpoints; it cannot be considered proof of efficacy for human depression.[1] ↗

PE-22-28—these conclusions apply to which study populations?＋

Mouse behavioral experiments and neuron culture. 2017; currently only 1 core original research directly related to the entity.[1] ↗

PE-22-28

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