P021P21

Images are illustrative. Actual specifications are as selected and confirmed in writing.

Cognitive & Neuro Research

P021

Learning, memory, cognition and neuroplasticity

P021 specifications and reference prices. Select a specification to add it to your cart.

5mg/vial x 10vials

Reference priceUS$429

For laboratory research only. Not for human or veterinary use.

COA 检测报告 / Reports

Compare all specifications & reference prices
SKUSpecification / packReference price (USD)
P215mg/vial x 10vialsUS$429

Temporarily sold-out specifications can still be added to an inquiry to ask about restocking. An inquiry is not an order or an agreed price.

RESEARCH FOCUS

Main Uses & FAQs

This page organizes directly relevant information on P021 regarding learning, memory, cognition, and neural plasticity. First, look at the research questions and findings, then verify the population or species, study preparations, and scope of interpretation.

Main TopicsLearning and memory · Cognition · Neuroplasticity
USAGE REFERENCE

P021 · Usage reference (for research purposes)

The following presents common research-context references for reconstitution, storage, dosage and cycles. The following presents common references in research settings. This page does not constitute advice for use in humans or animals.

🧪Reconstitution

Suggested Diluent
Bacteriostatic Water (containing 0.9% benzyl alcohol); some peptides may use sterile water or acetic acid to aid dissolution. See the individual product descriptions.
Diluent Volume
Slowly introduce the diluent along the vial wall until the lyophilized powder is covered. A common example is 5 mg reconstituted with 2 mL of bacteriostatic water, yielding approximately 2.5 mg/mL. Referenced reconstitution volumes are approximately 1–2.5 mL, with 2 mL commonly used. It is suggested to select and record a fixed volume based on the COA supplied with the purchase.
Handling Notes
Introduce the diluent slowly along the vial wall rather than directly onto the lyophilized powder. Leave it for 60–90 seconds to dissolve naturally; do not shake vigorously.

💾Storage

Unreconstituted Lyophilized Powder
Refrigerate at 2–8°C, protected from light; avoid repeated freeze–thaw cycles.
After Reconstitution
Refrigerate at 2–8°C; a common recommendation is touse within 28 days; do not freeze.
Transport
For short periods, use insulated packaging with ice packs; avoid high temperatures and direct light.

📏Dosage Reference (Research)

Purpose / SettingCommon Reference
ExplanationCognition Research, Human Protocol Limited

Note: The above describes common research-context references, rather than clinical recommendations. Refer to the batch COA and research protocol. For research use only; not for human or animal use.

Research SummaryKey Findings

What research findings exist regarding P021 in learning, memory, cognition, and neural plasticity?

P021 prevents some cognitive and synaptic function deficits. Other research reports: P021 improves subsequent cognitive function, tau, and amyloid pathology markers.[1] ↗ [2] ↗

Before ReadingStudy populations, species, formulations and delivery conditions each have a defined scope. Research on an ingredient does not establish that this site's product batches have been validated for efficacy in humans or veterinary use.
4 Main ReferencesSorted by First Publication Date ↓
Animal Study2021 · Historical basic researchREF. 01

What changes occurred in cognitive and synaptic markers following early P021 intervention?

Research Findings

P021 prevents some cognitive and synaptic function deficits.[1] ↗

Study Design

3xTg-AD mice; early postnatal dietary administration

Scope & Limitations

Early developmental intervention is not equivalent to treatment of patients who have already developed the disease in old age.

View the Article Title and Full Citation+

Neurotrophic Treatment Initiated During Early Postnatal Development Prevents the Alzheimer-Like Behavior and Synaptic Dysfunction.

Wei W, Liu Y, Dai CL, Baazaoui N, Tung YC, Liu F, Iqbal K

Journal of Alzheimer's Disease: JAD · Volume/Issue/Year 2021
First published 2021-01-01 · PMID 34057082
DOI 10.3233/JAD-201599

Animal Study2020 · Historical basic researchREF. 02

What statements can be supported by perinatal P021 animal interventions?

Research Findings

P021 improves subsequent cognitive function, tau, and amyloid pathology markers.[2] ↗

Study Design

3xTg-AD mice; prenatal to early postnatal period

Scope & Limitations

2020 developmental stage intervention; cannot extrapolate to use by pregnant women or infants.

View the Article Title and Full Citation+

Prenatal to early postnatal neurotrophic treatment prevents Alzheimer-like behavior and pathology in mice.

Wei W, Wang Y, Liu Y, Dai CL, Tung YC, Liu F, Iqbal K

Alzheimer's Research & Therapy · Volume and Year 2020
First published 2020-08-27 · PMID 32854771
DOI 10.1186/s13195-020-00666-7

Animal Study2017 · Historical basic researchREF. 03

What cognitive changes are observed with long-term P021 intervention?

Research Findings

Improves cognitive, dendritic, and synaptic indicators, and enhances neurogenesis.[3] ↗

Study Design

3xTg-AD mice; long-term dietary P021 intervention

Scope & Limitations

Diseased mice, early long-term intervention; cannot be extrapolated to cognitive improvement in healthy humans.

View the Article Title and Full Citation+

Prevention of dendritic and synaptic deficits and cognitive impairment with a neurotrophic compound.

Baazaoui N, Iqbal K

Alzheimer's Research & Therapy · Volume and Year 2017
First published 2017-06-27 · PMID 28655344
DOI 10.1186/s13195-017-0273-7

Animal Study2014 · Historical basic researchREF. 04

What Research Findings Exist on Cognition and Synaptic Indicators?

Research Findings

Improves cognition, neurogenesis, and synaptic plasticity, reducing some tau-related pathology.[4] ↗

Study Design

3xTg-AD mice; 12-month oral P021 study

Scope & Limitations

Animal AD model; cannot extrapolate to human treatment, not all pathological endpoints were confirmed to improve.

View the Article Title and Full Citation+

Disease modifying effect of chronic oral treatment with a neurotrophic peptidergic compound in a triple transgenic mouse model of Alzheimer's disease.

Kazim SF, Blanchard J, Dai CL, Tung YC, LaFerla FM, Iqbal IG, Iqbal K

Neurobiology of disease · Volume/Issue Year 2014
First published on 2014-07-15 · PMID 25046994
DOI 10.1016/j.nbd.2014.07.001

i

Currently, 4 original studies related to the theme of this page have been selected. The number of studies includes different designs, populations, or preparations, not commercial clinical efficacy ratings. This page is a usage-oriented positive data selection, not a systematic review or dosing recommendation. Historical studies, combination preparations, and special models are all separately indicated.

GO DEEPER

What Questions Do These Studies Address?

Compare study populations, findings and scope.

↗
QUESTIONS, ANSWERED

P021 · Frequently Asked Questions.

What research findings exist regarding P021 in learning, memory, cognition, and neural plasticity?+

P021 prevents some cognitive and synaptic function deficits. Other research reports: P021 improves subsequent cognitive function, tau, and amyloid pathology markers.[1] ↗ [2] ↗

Can cognitive studies of P021 be used to enhance memory in healthy individuals?+

No. Current data are mainly on AD-like mice, early or long-term interventions; improvements in cognition and synaptic indicators do not equal effects in healthy humans, and cannot be applied to pregnant women or infants.[1] ↗ [3] ↗ [4] ↗

P021—these conclusions apply to which study populations?+

3xTg-AD mice; early postnatal dietary administration; 3xTg-AD mice; prenatal to early postnatal period; 3xTg-AD mice; long-term dietary P021 intervention. Early developmental intervention is not the same as treating elderly patients who are already symptomatic.[1] ↗ [2] ↗ [3] ↗

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