Orexin AOA5

Images are illustrative. Actual specifications are as selected and confirmed in writing.

Cognitive & Neuro Research

Orexin A

Arousal, wakefulness and sleep regulation

Orexin A specifications and reference prices. Select a specification to add it to your cart.

5mg/vial x 10vials
Reference priceUS$205

For laboratory research only. Not for human or veterinary use.

COA 检测报告 / Reports

Compare all specifications & reference prices
SKUSpecification / packReference price (USD)
OA55mg/vial x 10vialsUS$205
OA1010mg/vial x 10vialsUS$370

Temporarily sold-out specifications can still be added to an inquiry to ask about restocking. An inquiry is not an order or an agreed price.

RESEARCH FOCUS

Main Uses & FAQs

This page organizes directly relevant information on Orexin A regarding arousal, wakefulness, and sleep regulation. First, look at the research questions and findings, then verify the population or species, study preparations, and scope of interpretation.

Main TopicsAwakening · Alertness · Sleep Regulation
USAGE REFERENCE

Orexin A · Usage reference (for research purposes)

The following presents common research-context references for reconstitution, storage, dosage and cycles. The following presents common references in research settings. This page does not constitute advice for use in humans or animals.

🧪Reconstitution

Suggested Diluent
Bacteriostatic Water (containing 0.9% benzyl alcohol); some peptides may use sterile water or acetic acid to aid dissolution. See the individual product descriptions.
Diluent Volume
Slowly introduce the diluent along the vial wall until the lyophilized powder is covered. A common example is 5 mg reconstituted with 2 mL of bacteriostatic water, yielding approximately 2.5 mg/mL. Referenced reconstitution volumes are approximately 1–2.5 mL, with 2 mL commonly used. It is suggested to select and record a fixed volume based on the COA supplied with the purchase.
Handling Notes
Introduce the diluent slowly along the vial wall rather than directly onto the lyophilized powder. Leave it for 60–90 seconds to dissolve naturally; do not shake vigorously.

💾Storage

Unreconstituted Lyophilized Powder
Refrigerate at 2–8°C, protected from light; avoid repeated freeze–thaw cycles.
After Reconstitution
Refrigerate at 2–8°C; a common recommendation is touse within 28 days; do not freeze.
Transport
For short periods, use insulated packaging with ice packs; avoid high temperatures and direct light.

📏Dosage Reference (Research)

Purpose / SettingCommon Reference
ExplanationAwakening/Sleep Research, Limited Information

Note: The above describes common research-context references, rather than clinical recommendations. Refer to the batch COA and research protocol. For research use only; not for human or animal use.

Research SummaryKey Findings

What research findings does Orexin A have regarding wakefulness, alertness, and sleep regulation?

Increased wakefulness and spontaneous activity suggest the regulation of arousal. Another study reports: some REM sleep stability and distribution attention error indicators improved.[1] ↗ [2] ↗

Before ReadingStudy populations, species, formulations and delivery conditions each have a defined scope. Research on an ingredient does not establish that this site's product batches have been validated for efficacy in humans or veterinary use.
3 Main ReferencesSorted by First Publication Date ↓
Animal Study2015 · Historical basic researchREF. 01

What wake-up mechanisms does microinjection research in the brain region illustrate?

Research Findings

Increased wakefulness and spontaneous activity suggest the regulation of arousal.[1] ↗

Study Design

Male rats; Orexin-A brain region microinjection study

Scope & Limitations

Special intracerebral delivery, cannot apply data from regular peripheral or nasal products.

View the Article Title and Full Citation+

Promotion of Wakefulness and Energy Expenditure by Orexin-A in the Ventrolateral Preoptic Area.

Mavanji V, Perez-Leighton CE, Kotz CM, Billington CJ, Parthasarathy S, Sinton CM, Teske JA

Sleep · Volume Issue Year 2015
First published on 2015-09-01 · PMID 25845696
DOI 10.5665/sleep.4970

Human Study2014 · Historical basic researchREF. 02

What findings were observed regarding sleep and attention with intranasal Orexin-A?

Research Findings

Partial REM sleep stability and distribution attention error indicators improved.[2] ↗

Study Design

14 narcolepsy patients with cataplexy; randomized double-blind intranasal crossover trial

Scope & Limitations

Small-sample acute experiment; cannot claim confirmed sustained awake efficacy, research nasal formulation differs from catalog products.

View the Article Title and Full Citation+

The effect of intranasal orexin-A (hypocretin-1) on sleep, wakefulness and attention in narcolepsy with cataplexy.

Weinhold SL, Seeck-Hirschner M, Nowak A, Hallschmid M, Göder R, Baier PC

Behavioural Brain Research · Volume/Issue Year 2014
First published on 2014-01-07 · PMID 24406723
DOI 10.1016/j.bbr.2013.12.045

Animal Study1999 · Historical basic researchREF. 03

What does research on neuronal activity and arousal in spots coeruleus indicate?

Research Findings

Orexin-A increases the activity of locus coeruleus neurons and wakefulness, providing a basis for the sleep-wake mechanism.[3] ↗

Study Design

Rats; Electrophysiology and arousal behavior in brain regions

Scope & Limitations

1999 Animal basic research, not human clinical administration evidence.

View the Article Title and Full Citation+

Orexin A activates locus coeruleus cell firing and increases arousal in the rat.

Hagan JJ, Leslie RA, Patel S, Evans ML, Wattam TA, Holmes S, Benham CD, Taylor SG, Routledge C, Hemmati P, Munton RP, Ashmeade TE, Shah AS, Hatcher JP, Hatcher PD, Jones DN, Smith MI, Piper DC, Hunter AJ, Porter RA, Upton N

Proceedings of the National Academy of Sciences of the United States of America · Volume and Issue Year 1999
First published 1999-09-14 · PMID 10485925
DOI 10.1073/pnas.96.19.10911

i

Currently, 3 original studies related to the theme of this page have been selected. The number of studies includes different designs, populations, or preparations, not commercial clinical efficacy ratings. This page is a usage-oriented positive data selection, not a systematic review or dosing recommendation. Historical studies, combination preparations, and special models are all separately indicated.

GO DEEPER

What Questions Do These Studies Address?

Compare study populations, findings and scope.

↗
QUESTIONS, ANSWERED

Orexin A · Frequently Asked Questions.

What research findings does Orexin A have regarding wakefulness, alertness, and sleep regulation?+

Increased wakefulness and spontaneous activity suggest the regulation of arousal. Another study reports: some REM sleep stability and distribution attention error indicators improved.[1] ↗ [2] ↗

Has nasal research on Orexin-A demonstrated the ability to maintain long-term wakefulness?+

None. The 14-person short-term crossover trial on this page mainly reports REM stability and some attention indicators; microinjection results in animal brains cannot be directly applied to regular dosing.[2] ↗ [1] ↗

Orexin A—these conclusions apply to which study populations?+

Male rats; Orexin-A brain region microinjection study; 14 patients with cataplexy-type narcolepsy; randomized double-blind nasal crossover trial; rats; brain region electrophysiology and wakefulness behavior. Special intracerebral delivery, cannot be applied to ordinary peripheral or nasal products.[1] ↗ [2] ↗ [3] ↗

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