MK677

Images are illustrative. Actual specifications are as selected and confirmed in writing.

Growth Hormone & IGF-1

MK677

Q: What research findings exist for MK677 regarding GH secretion, lean body mass, and body composition?

GH、IGF-I及去脂体重增加。 另有研究报告：MK-677改善负氮平衡，支持抗分解代谢研究。 原始文献：https://pubmed.ncbi.nlm.nih.gov/9467542/, https://pubmed.ncbi.nlm.nih.gov/9467534/

Q: Does MK-677 increasing lean body mass indicate fat loss or increased muscle strength?

不代表。8周人体试验中去脂体重增加，但总脂肪和内脏脂肪未显著减少，且有糖耐量变化；不能当作减脂或力量承诺。 原始文献：https://pubmed.ncbi.nlm.nih.gov/9467542/

Q: MK677—these conclusions apply to which study populations?

24名肥胖男性；8周口服MK-677随机双盲试验；人体随机双盲；饮食限制条件；健康老年成人；口服4周。总脂肪及内脏脂肪未显著下降，糖耐量受影响；不等同肌力、减脂或瓶装用法。 原始文献：https://pubmed.ncbi.nlm.nih.gov/9467542/, https://pubmed.ncbi.nlm.nih.gov/9467534/, https://pubmed.ncbi.nlm.nih.gov/8954023/

GH secretion, lean mass and body composition

MK677 specifications and reference prices. Select a specification to add it to your cart.

5mg/vial x 10vials

Reference priceUS$50

For laboratory research only. Not for human or veterinary use.

COA 检测报告 / Reports

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SKU	Specification / pack	Reference price (USD)
MK677	5mg/vial x 10vials	US$50

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RESEARCH FOCUS

Main Uses & FAQs

This page organizes directly relevant information on MK677 regarding GH secretion, lean body mass, and body composition. First, look at the research questions and findings, then verify the population or species, study preparations, and scope of interpretation.

Main TopicsGH secretion · lean body mass · body composition

What research findings exist for MK677 regarding GH secretion, lean body mass, and body composition?↗Does MK-677 increasing lean body mass indicate fat loss or increased muscle strength?↗MK677—these conclusions apply to which study populations?↗

References

Read the Full Research Review ↗

Research SummaryKey Findings

What research findings exist for MK677 regarding GH secretion, lean body mass, and body composition?

GH, IGF-I, and lean body mass increase. Other studies report: MK-677 improves negative nitrogen balance, supporting anti-catabolic research.[1] ↗ [2] ↗

Before ReadingStudy populations, species, formulations and delivery conditions each have a defined scope. Research on an ingredient does not establish that this site's product batches have been validated for efficacy in humans or veterinary use.

3 Main ReferencesSorted by First Publication Date ↓

Human Study1998 · Historical basic researchREF. 01

With lean body weight gain, does fat reduction also occur?

Research Findings

GH, IGF-I, and lean body mass increase.[1] ↗

Study Design

24 obese men; 8-week oral MK-677 randomized double-blind trial

Scope & Limitations

Total and visceral fat did not significantly decrease, glucose tolerance is affected; this is not equivalent to muscle strength, fat loss, or bottled usage.

View the Article Title and Full Citation＋

Two-month treatment of obese subjects with the oral growth hormone (GH) secretagogue MK-677 increases GH secretion, fat-free mass, and energy expenditure.

Svensson J, Lönn L, Jansson JO, Murphy G, Wyss D, Krupa D, Cerchio K, Polvino W, Gertz B, Boseaus I, Sjöström L, Bengtsson BA

The Journal of Clinical Endocrinology and Metabolism · Volume, Issue, Year 1998
First published 1998-02-01 · PMID 9467542
DOI 10.1210/jcem.83.2.4539

Human Study1998 · Historical basic researchREF. 02

How does nitrogen balance change under dietary restriction conditions?

Research Findings

MK-677 improves negative nitrogen balance, supporting anti-catabolic research.[2] ↗

Study Design

Random double-blind human condition; Dietary restriction condition

Scope & Limitations

1998 Short-term physiological study, cannot be turned into long-term muscle gain claims.

View the Article Title and Full Citation＋

MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism.

Murphy MG, Plunkett LM, Gertz BJ, He W, Wittreich J, Polvino WM, Clemmons DR.

The Journal of Clinical Endocrinology and Metabolism · Volume, Issue, Year 1998
First published 1998-02-01 · PMID 9467534
DOI 10.1210/jcem.83.2.4551

Human Study1996 · Historical basic researchREF. 03

What does the GH and IGF-I physiology study in healthy elderly reveal?

Research Findings

GH pulses and IGF-I increase, offering endocrinology development significance.[3] ↗

Study Design

Healthy elderly adults; 4-week oral study

Scope & Limitations

1996; accompanied by increased fasting blood glucose, cannot be described as safe anti-aging or guaranteed health benefits.

View the Article Title and Full Citation＋

Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects.

Chapman IM, Bach MA, Van Cauter E, Farmer M, Krupa D, Taylor AM, Schilling LM, Cole KY, Skiles EH, Pezzoli SS, Hartman ML, Veldhuis JD, Gormley GJ, Thorner MO.

The Journal of Clinical Endocrinology and Metabolism · Volume, Issue, Year 1996
First published 1996-12-01 · PMID 8954023.
DOI 10.1210/jcem.81.12.8954023

Currently, 3 original studies related to the theme of this page have been selected. The number of studies includes different designs, populations, or preparations, not commercial clinical efficacy ratings. This page is a usage-oriented positive data selection, not a systematic review or dosing recommendation. Historical studies, combination preparations, and special models are all separately indicated.

QUESTIONS, ANSWERED

MK677 · Frequently Asked Questions.

What research findings exist for MK677 regarding GH secretion, lean body mass, and body composition?＋

GH, IGF-I, and lean body mass increase. Other studies report: MK-677 improves negative nitrogen balance, supporting anti-catabolic research.[1] ↗ [2] ↗

Does MK-677 increasing lean body mass indicate fat loss or increased muscle strength?＋

Does not represent. In an 8-week human trial, lean body mass increased, but total fat and visceral fat did not decrease significantly, and there were changes in glucose tolerance; it cannot be taken as a promise of fat loss or strength increase.[1] ↗

MK677—these conclusions apply to which study populations?＋

24 obese men; 8-week oral MK-677 randomized double-blind trial; human randomized double-blind; dietary restriction conditions; healthy older adults; 4 weeks oral. Total fat and visceral fat did not drop significantly, glucose tolerance affected; not equivalent to muscle strength, fat loss, or bottle usage.[1] ↗ [2] ↗ [3] ↗

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MK677

COA 检测报告 / Reports

Main Uses & FAQs

References

What research findings exist for MK677 regarding GH secretion, lean body mass, and body composition?

With lean body weight gain, does fat reduction also occur?

Two-month treatment of obese subjects with the oral growth hormone (GH) secretagogue MK-677 increases GH secretion, fat-free mass, and energy expenditure.

How does nitrogen balance change under dietary restriction conditions?

MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism.

What does the GH and IGF-I physiology study in healthy elderly reveal?

Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects.

What Questions Do These Studies Address?

MK677 · Frequently Asked Questions.

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